The third Phantasy Star game, subtitled Generations of Doom, was released for the Megadrive by Sega in 1990.
Cosmic Spacehead is a 1993 Sega Megadrive release for British publisher Codemasters. It is, in fact, an enhanced remake of a previous Codemasters game, Linus Spacehead’s Cosmic Crusade.
Developed by Johnson Voorsanger Productions for Sega and published on the Megadrive in 1991, Toejam & Earl is a cult collect ’em up starring two alien rappers who have crash-landed on Earth.
Castlevania: Bloodlines was released for the Sega Megadrive by Konami in 1993. It was the only Castlevania game ever released for the Megadrive.
Pier Solar and the Great Architects is a famous homebrew Role-Playing Game released in 2010. It was developed by a team called WaterMelon and was initially released on cartridge exclusively for the Sega Megadrive.
Since then, though, it has been ported to a number of different platforms, including HD remakes for Dreamcast, PlayStation 3 & 4, Wii U, PC, XBox One, and Android.
Delphine Software‘s classic futuristic adventure game, Flashback, came out first on the Amiga in 1992 but was originally developed with the Sega Megadrive as its target platform.
Timing and cartridge production issues meant that it came out after a number of other ports had already been released, but that didn’t dent enthusiasm for the game on the Megadrive.
Alex Kidd in the Enchanted Castle is a 1989 platform game released for the Sega Megadrive/Genesis. It was developed in-house by Sega as a competitor to the Nintendo Mario games, which were hugely popular at the time.
MUSHA is a well-liked Megadrive shooter, made by famed Japanese developer Compile. It is part of the Aleste series, but features a ‘mecha’-suited protagonist fighting against a super computer that has taken over the Earth, rather than a spaceship.
I have said previously on this blog that no system is complete without a version of Hudson Soft‘s Bomberman, and the Megadrive has one in the form of Mega Bomberman.