The Adventures of Batman & Robin is considered to be one of the most technically-impressive games on the Sega Megadrive. It was developed by Clockwork Tortoise, Inc. and published by Sega in 1995.
This 1991 Sega Megadrive conversion of Toki is only loosely-based on the original 1989 arcade game, which is good because the original was much too hard to be fun, and this is more playable.
The third Phantasy Star game, subtitled Generations of Doom, was released for the Megadrive by Sega in 1990.
Cosmic Spacehead is a 1993 Sega Megadrive release for British publisher Codemasters. It is, in fact, an enhanced remake of a previous Codemasters game, Linus Spacehead’s Cosmic Crusade.
Developed by Johnson Voorsanger Productions for Sega and published on the Megadrive in 1991, Toejam & Earl is a cult collect ’em up starring two alien rappers who have crash-landed on Earth.
Castlevania: Bloodlines was released for the Sega Megadrive by Konami in 1993. It was the only Castlevania game ever released for the Megadrive.
Pier Solar and the Great Architects is a famous homebrew Role-Playing Game released in 2010. It was developed by a team called WaterMelon and was initially released on cartridge exclusively for the Sega Megadrive.
Since then, though, it has been ported to a number of different platforms, including HD remakes for Dreamcast, PlayStation 3 & 4, Wii U, PC, XBox One, and Android.
Delphine Software‘s classic futuristic adventure game, Flashback, came out first on the Amiga in 1992 but was originally developed with the Sega Megadrive as its target platform.
Timing and cartridge production issues meant that it came out after a number of other ports had already been released, but that didn’t dent enthusiasm for the game on the Megadrive.